Improved alpharetrovirus-based Gag.MS2 particles for efficient and transient delivery of CRISPR-Cas9 into target cells

Improved alpharetrovirus-based Gag.MS2 particles for efficient and transient delivery of CRISPR-Cas9 into target cells

DNA-modifying technologies, such as the CRISPR-Cas9 system, are promising tools in the field of gene and cell therapies. However, high and prolonged expression of DNA-modifying enzymes may cause cytotoxic and genotoxic side effects and is therefore unwanted in therapeutic approaches. Consequently, d...

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Main Authors: Yvonne Baron (Author), Johanna Sens (Author), Lucas Lange (Author), Larissa Nassauer (Author), Denise Klatt (Author), Dirk Hoffmann (Author), Marc-Jens Kleppa (Author), Philippe Vollmer Barbosa (Author), Maximilian Keisker (Author), Viviane Steinberg (Author), Julia D. Suerth (Author), Florian W.R. Vondran (Author), Johann Meyer (Author), Michael Morgan (Author), Axel Schambach (Author), Melanie Galla (Author)
Format: Book
Published: Elsevier, 2022-03-01T00:00:00Z.
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