Effect of Ampicillin on the kinetics of colonization of <it>Streptococcus pneumoniae </it>and <it>Lactobacillus fermentum </it>in the respiratory tract of mice
<p>Abstract</p> <p>Ampicillin was selected to further study the effect of this antibiotic on the colonization capability of <it>S. pneumoniae </it>and <it>L. fermentum </it>intranasally inoculated in a mice experimental model. The sensitivity of <it>S....
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| Main Authors: | , , , , |
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| Format: | Book |
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BMC,
2004-10-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | <p>Abstract</p> <p>Ampicillin was selected to further study the effect of this antibiotic on the colonization capability of <it>S. pneumoniae </it>and <it>L. fermentum </it>intranasally inoculated in a mice experimental model. The sensitivity of <it>S. pneumoniae </it>and <it>L. fermentum </it>to antibiotics was evaluated by different "in vitro" techniques. The results showed that both microorganisms have a typical pattern of sensitivity to antibiotics in these assays. The "in vivo" experiments showed that the treatment with Ampicillin increased the number of lactobacilli and <it>neumococci </it>in the groups of mice treated only with one of the microorganisms. In those mice treated with <it>Lactobacillus</it>, challenged later with <it>neumococci </it>and treated with Ampicillin, the pathogen in lung decreased on the 4<sup>th </sup>day, disappearing completely after on. The histological studies showed that the antibiotic treatment decreased the inflammatory response produced by the pathogen at the lung and trachea levels.</p> |
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| Item Description: | 10.1186/1476-0711-3-23 1476-0711 |