Development of a Hierarchical Support Vector Regression-Based In Silico Model for Caco-2 Permeability

• Main Authors: Giang Huong Ta (Author), Cin-Syong Jhang (Author), Ching-Feng Weng (Author), Max K. Leong (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug absorption is one of the critical factors that should be taken into account in the process of drug discovery and development. The human colon carcinoma cell layer (Caco-2) model has been frequently used as a surrogate to preliminarily investigate the intestinal absorption. In this study, a quan...