A <it>de novo </it>complete <it>BRCA1 </it>gene deletion identified in a Spanish woman with early bilateral breast cancer

• Autori principali: Llombart Pilar (Autore), Garcia Ana (Autore), Llopis Francisco (Autore), Rubio Luis (Autore), Fernandez-Serra Antonio (Autore), Romero Ignacio (Autore), Garcia-Casado Zaida (Autore), Lopez-Guerrero Jose A (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2011-10-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Germline mutations in either of the two tumor-suppressor genes, <it>BRCA1 </it>and <it>BRCA2</it>, account for a significant proportion of hereditary breast and ovarian cancer cases. Most of these mutations co...