Validation of a rabbit model of irradiated bone healing: preliminary report
Introduction: External radiotherapy can lead to severe bone alteration. The aim of this pilot study was to validate a model for assessment of postextractional bone healing in the irradiated rabbit mandible. Material and method: The radiation protocol consisted of 5 sessions delivering 8.5 Gy each. S...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Book |
| Published: |
EDP Sciences,
2020-01-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Introduction: External radiotherapy can lead to severe bone alteration. The aim of this pilot study was to validate a model for assessment of postextractional bone healing in the irradiated rabbit mandible. Material and method: The radiation protocol consisted of 5 sessions delivering 8.5 Gy each. Surgery was performed immediately after completion of radiotherapy. Sacrifices were performed from Day 0 to Day 42. Results: The bone mineral density and the trabecular number were decreased after radiotherapy whereas trabecular separation increased. The main differences between irradiated and non-irradiated rabbits were observed at Day 28 and 42. Discussion: Radiation seems to cause a delay in bone healing. It decreases bone quality and bone mineral density. Five sessions seem to be a valuable compromise between tissues effect and feasibility of the experiment. Conclusion: This model seems to be valuable for evaluating postextractional bone healing in the irradiated rabbit mandible. |
|---|---|
| Item Description: | 2608-1326 10.1051/mbcb/2020012 |