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The mutant of rs2075604 in STK11 improves HDL-c levels among newly diagnosed type 2 diabetes mellitus patients

Context: Type 2 diabetes mellitus (T2DM) patients tend to have lipid abnormalities, thus elevating the risk of complications and mortality. Early detection using a genomic approach could help identify the abnormality of lipid profiles so that it could reduce those burdens. A previous study found a h...

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Main Authors: Dita Maria Virginia (Author), Christine Patramurti (Author), Phebe Hendra (Author), Paulina Nadya Feranti Pebby Lorenza (Author), Faustina Evania Ngai (Author), Novita Anastasia (Author), Matea Nirmala Defi (Author), Mae Sri Hartati Wahyuningsih (Author), Dwi Aris Agung Nugrahaningsih (Author)
Format: Book
Published: GarVal Editorial Ltda., 2023-03-01T00:00:00Z.
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Summary:Context: Type 2 diabetes mellitus (T2DM) patients tend to have lipid abnormalities, thus elevating the risk of complications and mortality. Early detection using a genomic approach could help identify the abnormality of lipid profiles so that it could reduce those burdens. A previous study found a high frequency of mutants in the rs2075604 as the intron area in the STK11 gene. Aims: To analyze the effect of rs2075604 related to lipid abnormalities in newly diagnosed T2DM patients. Methods: This present study conducted a cross-sectional study in the ten public healthcare facilities in Sleman, Yogyakarta. The genetic variants were detected using PCR-RFLP methods. A total of 130 patients who had to consume antidiabetic oral for three months participated in this study. Results: This study revealed that the mutant variant dominated in this population at 61.5%. Mutant genotype, mutant allele, and dominant model reduce the risk of low HDL (OR = 0.33, 95% CI = 0.11-0.99; OR = 0.46, 95% CI = 0.24-0.90; OR = 0.33, 95% CI = 0.12-0.96; respectively). The improvement of low HDL risk by the mutant allele was confirmed through an adjusted model (OR = 0.47, 95% CI = 0.23-0.98). The mutant allele only influenced high LDL risk in the non-adjusted model (OR = 2.22, 95% CI = 1.02-4.82), but it did not found in other models. Conclusions: The mutant of rs2075604 has a protective role in low HDL-c risk in Indonesia. However, further study is required to observe the effect on LDL-c.
Item Description:10.56499/jppres22.1541_11.2.255
0719-4250

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