In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II

• Main Authors: Mohamed Badr (Author), Elshaymaa I. Elmongy (Author), Doaa Elkhateeb (Author), Yasmine S. Moemen (Author), Ashraf Khalil (Author), Hadeer Ali (Author), Reem Binsuwaidan (Author), Feby Awadallah (Author), Ibrahim El Tantawy El Sayed (Author)
• Format: Book
• Published: MDPI AG, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Sulfonamide acridine derivatives have garnered significant attention from medicinal chemists due to their diverse range of biological activities. Methods: In this study, eleven compounds were synthesized according to the literature, and their impact on cell growth inhibition, induction o...