Linking <i>S. aureus</i> Immune Evasion Mechanisms to Staphylococcal Vaccine Failures
Vaccination arguably remains the only long-term strategy to limit the spread of <i>S. aureus</i> infections and its related antibiotic resistance. To date, however, all staphylococcal vaccines tested in clinical trials have failed. In this review, we propose that the failure of <i>...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Published: |
MDPI AG,
2024-04-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Vaccination arguably remains the only long-term strategy to limit the spread of <i>S. aureus</i> infections and its related antibiotic resistance. To date, however, all staphylococcal vaccines tested in clinical trials have failed. In this review, we propose that the failure of <i>S. aureus</i> vaccines is intricately linked to prior host exposure to <i>S. aureus</i> and the pathogen's capacity to evade adaptive immune defenses. We suggest that non-protective immune imprints created by previous exposure to <i>S. aureus</i> are preferentially recalled by SA vaccines, and IL-10 induced by S. aureus plays a unique role in shaping these non-protective anti-staphylococcal immune responses. We discuss how <i>S. aureus</i> modifies the host immune landscape, which thereby necessitates alternative approaches to develop successful staphylococcal vaccines. |
|---|---|
| Item Description: | 10.3390/antibiotics13050410 2079-6382 |