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Selectivity analyses of γ-benzylidene digoxin derivatives to different Na,K-ATPase α isoforms: a molecular docking approach

Digoxin and other cardiotonic steroids (CTS) exert their effect by inhibiting Na,K-ATPase (NKA) activity. CTS bind to the various NKA isoforms that are expressed in different cell types, which gives CTS their narrow therapeutic index. We have synthesised a series of digoxin derivatives (γ-Benzyliden...

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Príomhchruthaitheoirí:	Marco T. C. Pessôa (Údar), Silmara L. G. Alves (Údar), Alex G. Taranto (Údar), José A. F. P. Villar (Údar), Gustavo Blanco (Údar), Leandro A. Barbosa (Údar)
Formáid:	LEABHAR
Foilsithe / Cruthaithe:	Taylor & Francis Group, 2018-01-01T00:00:00Z.
Ábhair:	article
Rochtain ar líne:	Connect to this object online.
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