The effect of platelet-rich plasma on the improvement of pregnancy results in repeated implantation failure: A randomized controlled trial

Abstract Background: The success rate of infertility treatment depends on many different factors. Objective: This study aimed to determine the effect of platelet-rich plasma (PRP) on the improvement of pregnancy outcomes in participants with repeated implantation failure. Materials and Methods: The...

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Main Authors: Elaheh Baybordi (Author), Jafar Mohseni (Author), Parisa Mosapour (Author)
Format: Book
Published: Shahid Sadoughi University of Medical Sciences, 2022-09-01T00:00:00Z.
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Summary:Abstract Background: The success rate of infertility treatment depends on many different factors. Objective: This study aimed to determine the effect of platelet-rich plasma (PRP) on the improvement of pregnancy outcomes in participants with repeated implantation failure. Materials and Methods: The study is a randomized triple-blind clinical trial. The study population was 118 women with repeated implantation failure during assisted reproductive technology treatment at Tabriz Jihad-e Daneshgahi ART Center from May 2017 to December 2019. Intervention: Intrauterine injection of autologous PRP. Standard treatment of fetal transfer to the uterine cavity was performed without intrauterine PRP injection in the control group: After 4 wk, the level of β-human chorionic gonadotropin hormone in participants' blood was measured. Results: Comparing the effect of intrauterine injection of PRP in 2 groups showed the level of β-human chorionic gonadotropin positive in the intervention group was 21 (43.8%), in the control group was 12 (26.1%), odds ratio = 2.20 (0.92-5.26) and p = 0.073. Conclusion: The therapeutic effect in the intervention group compared to the control regarding the outcome of a successful pregnancy showed that intrauterine injection of PRP can be effective in improving pregnancy outcomes, although this improvement is not significant.
Item Description:2476-4108
2476-3772
10.18502/ijrm.v20i9.12065