NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis

• Main Authors: Xiaoli Fan (Author), Dandan Yin (Author), Ruoting Men (Author), Heng Xu (Author), Li Yang (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Fag: article
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The aim of this study was to investigate the influence of NUDT15 R139C and thiopurine S-methyltransferase (TPMT) on azathioprine (AZA) induced leukopenia in patients with autoimmune hepatitis (AIH) and related cirrhosis. A total of 149 Chinese AIH patients with a history of AZA treatment were retros...