NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis

• Главные авторы: Xiaoli Fan (Автор), Dandan Yin (Автор), Ruoting Men (Автор), Heng Xu (Автор), Li Yang (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Предметы: article
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The aim of this study was to investigate the influence of NUDT15 R139C and thiopurine S-methyltransferase (TPMT) on azathioprine (AZA) induced leukopenia in patients with autoimmune hepatitis (AIH) and related cirrhosis. A total of 149 Chinese AIH patients with a history of AZA treatment were retros...