Co-Amorphous Screening for the Solubility Enhancement of Poorly Water-Soluble Mirabegron and Investigation of Their Intermolecular Interactions and Dissolution Behaviors

• Main Authors: Ji-Hun An (Author), Changjin Lim (Author), Alice Nguvoko Kiyonga (Author), In Hwa Chung (Author), In Kyu Lee (Author), Kilwoong Mo (Author), Minho Park (Author), Wonno Youn (Author), Won Rak Choi (Author), Young-Ger Suh (Author), Kiwon Jung (Author)
• Format: Book
• Published: MDPI AG, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present study, the screening of Mirabegron (MBR) co-amorphous was performed to produce water-soluble and thermodynamically stable MBR co-amorphous with the purpose of overcoming the water solubility problem of MBR. MBR is Biopharmaceutics Classification System (BCS) class II drug used for the...