The Influence of Antibiotic Resistance on Innate Immune Responses to <i>Staphylococcus aureus</i> Infection

• Main Authors: Nazneen Jahan (Author), Timothy Patton (Author), Meredith O'Keeffe (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<i>Staphylococcus aureus</i> (<i>S. aureus</i>) causes a broad range of infections and is associated with significant morbidity and mortality. <i>S. aureus</i> produces a diverse range of cellular and extracellular factors responsible for its invasiveness and ability to resist immune attack. In recent years, increasing resistance to last-line anti-staphylococcal antibiotics daptomycin and vancomycin has been observed. Resistant strains of <i>S. aureus</i> are highly efficient in invading a variety of professional and nonprofessional phagocytes and are able to survive inside host cells. Eliciting immune protection against antibiotic-resistant <i>S. aureus</i> infection is a global challenge, requiring both innate and adaptive immune effector mechanisms. Dendritic cells (DC), which sit at the interface between innate and adaptive immune responses, are central to the induction of immune protection against <i>S. aureus</i>. However, it has been observed that <i>S. aureus</i> has the capacity to develop further antibiotic resistance and acquire increased resistance to immunological recognition by the innate immune system. In this article, we review the strategies utilised by <i>S. aureus</i> to circumvent antibiotic and innate immune responses, especially the interaction between <i>S. aureus</i> and DC, focusing on how this relationship is perturbed with the development of antibiotic resistance.

Item Description

10.3390/antibiotics11050542
2079-6382