Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

• Main Authors: Víctor Farré-Alins (Author), Paloma Narros-Fernández (Author), Alejandra Palomino-Antolín (Author), Céline Decouty-Pérez (Author), Ana Belen Lopez-Rodriguez (Author), Esther Parada (Author), Alicia Muñoz-Montero (Author), Vanessa Gómez-Rangel (Author), Francisco López-Muñoz (Author), Eva Ramos (Author), Águeda González-Rodríguez (Author), Luis Gandía (Author), Alejandro Romero (Author), Javier Egea (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microglia controls the immune system response in the brain. Specifically, the activation and dysregulation of the NLRP3 inflammasome is responsible for the initiation of the inflammatory process through IL-1β and IL-18 release. In this work, we have focused on studying the effect of melatonin on the...