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Clinical and hematological characteristics of children infected with the omicron variant of SARS-CoV-2: role of the combination of the neutrophil: lymphocyte ratio and eosinophil count in distinguishing severe COVID-19

PurposeInvestigate the clinical/hematological characteristics of children infected with the Omicron variant of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and identify an effective indicator to distinguish coronavirus disease 2019 (COVID-19) severity in children.MethodsA retrospecti...

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Main Authors: Qiaoyan Jin (Author), Wenxian Ma (Author), Wei Zhang (Author), Huiyuan Wang (Author), Yiongxiang Geng (Author), Yan Geng (Author), Yang Zhang (Author), Dan Gao (Author), Jing Zhou (Author), Lin Li (Author), Yaping Gou (Author), Bo Zhong (Author), Jing Li (Author), Wei Hou (Author), Shemin Lu (Author)
Format: Book
Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
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Summary:PurposeInvestigate the clinical/hematological characteristics of children infected with the Omicron variant of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and identify an effective indicator to distinguish coronavirus disease 2019 (COVID-19) severity in children.MethodsA retrospective study was conducted through electronic medical records from pediatric patients. The demographic, clinical, and routine blood test (RBT) features of children diagnosed by real-time PCR for SARS-CoV-2 were collected.ResultsData of 261 patients were analyzed. The most common abnormality shown by RBTs was increased monocyte count (68%). Children had "mild-moderate" or "severe" forms of COVID-19. Prevalence of abnormal neutrophil count (p = 0.048), eosinophil count (p = 0.006), mean corpuscular volume (p = 0.033), mean platelet volume (p = 0.006), platelet-large cell ratio (p = 0.043), and red blood cell distribution width-standard deviation (p = 0.031) were significantly different in the two types. A combination of the neutrophil: lymphocyte ratio (NLR) and eosinophil count for diagnosing severe COVID-19 presented the largest AUC (0.688, 95% CI = 0.599-0.777; p < 0.001), and the AUC increased with a decrease in age.ConclusionsCombination of the NLR and eosinophil count might be a promising indicator for identifying severe COVID-19 in children at infection onset.
Item Description:2296-2360
10.3389/fped.2024.1305639

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