Mutation screen in the GWAS derived obesity gene <it>SH2B1</it> including functional analyses of detected variants

• Main Authors: Volckmar Anna-Lena (Author), Bolze Florian (Author), Jarick Ivonne (Author), Knoll Nadja (Author), Scherag André (Author), Reinehr Thomas (Author), Illig Thomas (Author), Grallert Harald (Author), Wichmann Heinz-Erich (Author), Wiegand Susanna (Author), Biebermann Heike (Author), Krude Heiko (Author), Fischer-Posovszky Pamela (Author), Rief Winfried (Author), Wabitsch Martin (Author), Klingenspor Martin (Author), Hebebrand Johannes (Author), Hinney Anke (Author)
• Format: Book
• Published: BMC, 2012-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The <it>SH2B1</it> gene (Src-homology 2B adaptor protein 1 gene) is a solid candidate gene for obesity. Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential relevance fo...