Spectrophotometric Determination of Cefixime Following Simple Diazotization and Coupling with ?-Naphthol
Cefixime (CFX) was treated with sodium nitrite and hydrochloric acid for diazotization reaction followed by coupling with ?-Naphthol in alkaline medium to form, a yellow colored azo dye compound which exhibits maximum absorption (?max) at 412 nm where the concentration of (CFX) was determined spectr...
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Published: |
College of Pharmacy University of Baghdad,
2017-12-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_7f9da6a0d7ad45c5894856a0b79b7c01 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Samar A. Darweesh |e author |
| 245 | 0 | 0 | |a Spectrophotometric Determination of Cefixime Following Simple Diazotization and Coupling with ?-Naphthol |
| 260 | |b College of Pharmacy University of Baghdad, |c 2017-12-01T00:00:00Z. | ||
| 500 | |a 10.31351/vol26iss2pp1-6 | ||
| 500 | |a 1683-3597 | ||
| 500 | |a 2521-3512 | ||
| 520 | |a Cefixime (CFX) was treated with sodium nitrite and hydrochloric acid for diazotization reaction followed by coupling with ?-Naphthol in alkaline medium to form, a yellow colored azo dye compound which exhibits maximum absorption (?max) at 412 nm where the concentration of (CFX) was determined spectrophotometrically. The optimum reaction conditions and other analytical parameters were evaluated. Beer's law was obeyed in the concentration range of (1-20) ?g.mL-1 with a molar absorptivity of 34870.5 L.mol-1.cm-1. The limit of detection was found to be 0.1090 ?g.mL-1 and the Sandell's sensitivity value was 0.0130 ?g.cm-2. The proposed method could be successfully applied to the determination of (CFX) in pharmaceutical formulations. | ||
| 546 | |a EN | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Iraqi Journal of Pharmaceutical Sciences, Vol 26, Iss 2 (2017) | |
| 787 | 0 | |n https://www.bijps.uobaghdad.edu.iq/index.php/bijps/article/view/726 | |
| 787 | 0 | |n https://doaj.org/toc/1683-3597 | |
| 787 | 0 | |n https://doaj.org/toc/2521-3512 | |
| 856 | 4 | 1 | |u https://doaj.org/article/7f9da6a0d7ad45c5894856a0b79b7c01 |z Connect to this object online. |