Inhibitory Effects of Rhaponticin on Osteoclast Formation and Resorption by Targeting RANKL-Induced NFATc1 and ROS Activity

• Main Authors: Jianbo He (Author), Kai Chen (Author), Tiancheng Deng (Author), Jiewei Xie (Author), Kunjing Zhong (Author), Jinbo Yuan (Author), Ziyi Wang (Author), Zhifeng Xiao (Author), Ronghe Gu (Author), Delong Chen (Author), Xiaojuan Li (Author), Dingkun Lin (Author), Jiake Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The extravagant osteoclast formation and resorption is the main cause of osteoporosis. Inhibiting the hyperactive osteoclastic resorption is considered as an efficient treatment for osteoporosis. Rhaponticin (RH) is a small molecule that has been reported to possess anti-inflammatory, anti-allergic,...