AGO-accessible anticancer siRNAs designed with synergistic miRNA-like activity

• Main Authors: Dowoon Gu (Author), Seung Hyun Ahn (Author), Sangkyeong Eom (Author), Hye-Sook Lee (Author), Juyoung Ham (Author), Dong Ha Lee (Author), You Kyung Cho (Author), Yongjun Koh (Author), Elizaveta Ignatova (Author), Eun-Sook Jang (Author), Sung Wook Chi (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small interfering RNAs (siRNAs) therapeutically induce RNA interference (RNAi) of disease-causing genes, but they also silence hundreds of seed-matched off-targets as behaving similar to microRNAs (miRNAs). miRNAs control the pathophysiology of tumors, wherein their accessible binding sites can be s...