Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains

• Main Authors: Stephen eToth (Author), Ernst E Brueggemann (Author), George A Oyler (Author), Leonard A Smith (Author), Harry B. Hines (Author), S. Ashraf eAhmed (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Botulinum neurotoxins are most potent of all toxins. Their N-terminal light chain domain (Lc) translocates into peripheral cholinergic neurons to exert its endoproteolytic action leading to muscle paralysis. Therapeutic development against these toxins is a major challenge due to their in vitro and...