The Apelin/APJ System in Psychosis and Neuropathy
Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in d...
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| Main Authors: | , , |
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| Format: | Book |
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Frontiers Media S.A.,
2020-03-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals. The apelin/APJ system has been implicated in diverse physiological and pathological processes. The present article reviews the progress of the latest research investigating the apelin/APJ system in pain, depression, anxiety, memory, epilepsy, neuroprotection, stroke, and brain injury and protection, and highlights its promising potential as a therapeutic target for treatment of psychosis and neuropathy. |
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| Item Description: | 1663-9812 10.3389/fphar.2020.00320 |