Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report

Lacosamide (Vimpat Harris FRC Corporation, 2022 UCB, Inc. Smyrna, GA 30080) is an antiseizure medication, which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favor...

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Main Authors: Trassanee Chatmethakul (Author), Amy H. Stanford (Author), Danielle R. Rios (Author), Adrianne R. Bischoff (Author), Theresa Czech (Author), Patrick J. McNamara (Author)
Format: Book
Published: Thieme Medical Publishers, Inc., 2024-07-01T00:00:00Z.
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100 1 0 |a Trassanee Chatmethakul  |e author 
700 1 0 |a Amy H. Stanford  |e author 
700 1 0 |a Danielle R. Rios  |e author 
700 1 0 |a Adrianne R. Bischoff  |e author 
700 1 0 |a Theresa Czech  |e author 
700 1 0 |a Patrick J. McNamara  |e author 
245 0 0 |a Cardiac Dysfunction Associated with Lacosamide in a Premature Infant with Hypoxic Ischemic Encephalopathy: A Case Report 
260 |b Thieme Medical Publishers, Inc.,   |c 2024-07-01T00:00:00Z. 
500 |a 2157-6998 
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500 |a 10.1055/a-2447-8662 
520 |a Lacosamide (Vimpat Harris FRC Corporation, 2022 UCB, Inc. Smyrna, GA 30080) is an antiseizure medication, which acts through blockage of voltage-gated neuronal sodium channels. Its recent implementation in the neonatal population has been extrapolated from adult and pediatric data suggesting a favorable safety profile. Of note, preterm infants have unique developmental characteristics that may predispose them to increased risk of adverse reactions. We present a case of a preterm neonate who developed left ventricular dysfunction coinciding with the initiation of lacosamide. 
546 |a EN 
690 |a cardiac dysfunction 
690 |a antiseizure medication 
690 |a preterm infant 
690 |a lacosamide 
690 |a Gynecology and obstetrics 
690 |a RG1-991 
655 7 |a article  |2 local 
786 0 |n American Journal of Perinatology Reports, Vol 14, Iss 04, Pp e270-e273 (2024) 
787 0 |n http://www.thieme-connect.de/DOI/DOI?10.1055/a-2447-8662 
787 0 |n https://doaj.org/toc/2157-6998 
787 0 |n https://doaj.org/toc/2157-7005 
856 4 1 |u https://doaj.org/article/801c7c9c6bc44cd59d49e14f9f3437a3  |z Connect to this object online.