Revisiting the Solubility-Permeability Relationship with Hydrophobic Drug Umifenovir in Pluronic Solutions: Impact of pH and Co-Solvent

• Auteurs principaux: Tatyana Volkova (Auteur), Olga Simonova (Auteur), German Perlovich (Auteur)
• Format: Livre
• Publié: MDPI AG, 2023-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

This study describes the influence of pluronic F-127 (F-127) and ethanol (EtOH) on the solubility of umifenovir (UMF) in buffer solutions of pH 2.0 and pH 7.4, and its permeability through cellulose membranes. A 44.4-fold greater UMF solubility in acidic medium as compared to an alkaline one was est...