Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR

• Autors principals: Fangfang Wang (Autor), Sora Jin (Autor), Franklin Mayca Pozo (Autor), Danmei Tian (Autor), Xiyang Tang (Autor), Yi Dai (Autor), Xinsheng Yao (Autor), Jinshan Tang (Autor), Youwei Zhang (Autor)
• Format: Llibre
• Publicat: Elsevier, 2022-03-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

DNA damage response (DDR) is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs. Hence, small molecules that inhibit DDR are expected to enhance the anti-cancer effect of chemotherapy. Through a recent chemical library screen, we...