Anti-Angiogenic and Anti-Scarring Dual Action of an Anti-Fibroblast Growth Factor 2 Aptamer in Animal Models of Retinal Disease

• Main Authors: Yusaku Matsuda (Author), Yosuke Nonaka (Author), Satoshi Futakawa (Author), Hirotaka Imai (Author), Kazumasa Akita (Author), Toshiaki Nishihata (Author), Masatoshi Fujiwara (Author), Yusuf Ali (Author), Robert B. Bhisitkul (Author), Yoshikazu Nakamura (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently approved therapies for age-related macular degeneration (AMD) are inhibitors against vascular endothelial growth factor (VEGF), which is a major contributor to the pathogenesis of neovascular AMD (nAMD). Intravitreal injections of anti-VEGF drugs have shown dramatic visual benefits for AMD...