Multiplex ligation-dependent probe amplification versus karyotyping in prenatal diagnosis: the M.A.K.E. study

• Main Authors: Bhola Shama L (Author), Creemers Johan (Author), Go Attie (Author), Hoffer Mariëtte VJ (Author), Huijsdens Karin (Author), Kooper Angelique JA (Author), Macville Merryn VE (Author), Nijhuis Jan G (Author), van Oppen Carla AC (Author), Oepkes Dick (Author), Schuring-Blom Heleen G (Author), Wildschut Hajo I (Author), Birnie Erwin (Author), Boormans Elisabeth MA (Author), Bilardo Katia M (Author), Suijkerbuijk Ron (Author), Bouman Katelijne (Author), Galjaard Robert-Jan H (Author), Bonsel Gouke J (Author), van Lith Jan MM (Author)
• Format: Book
• Published: BMC, 2008-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>In the past 30 years karyotyping was the gold standard for prenatal diagnosis of chromosomal aberrations in the fetus. Traditional karyotyping (TKT) has a high accuracy and reliability. However, it is labor intensive, the results tak...