Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy
Small interfering RNAs (siRNAs) have potential to silence virtually any disease-causing gene but require chemical modifications for delivery to the tissue and cell of interest. Previously, we demonstrated that asymmetric, phosphorothioate (PS)-modified, chemically stabilized, cholesterol-conjugated...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
Elsevier,
2020-09-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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