Serum vitamin D levels in high-risk HPV infected patients, is there any relation?

• Main Authors: Anil Turhan Cakir (Author), Muhammet Atay Ozten (Author)
• Format: Book
• Published: National Scientific Medical Center, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1812-2892; 2313-1519; 10.23950/jcmk/12113
• Keywords: human papillomavirus; vitamin D; cervix uteri; Internal medicine; RC31-1245; Specialties of internal medicine; RC581-951
• Source: Ķazaķstannyṇ Klinikalyķ Medicinasy, Vol 19, Iss 3, Pp 35-39 (2022)

<b>Objective:</b> Human Papilloma Virus (HPV) is a sexually transmittable virus and is the main etiologic cause of uterine cervical cancers. Beyond that, vitamin D is a steroid structured lipid-soluble vitamin, enhancing both humoral and cellular immune responses. In our study, we aimed to investigate the relationship between vitamin D levels and high-risk HPV infections.<br /> <b>Material and methods: </b>A total of 143 patients who applied to the gynecology outpatient clinic between June 2020 and August 2020 were included in the study. Patients with high-risk HPV positivity constituted the study group, and HPV-negative patients constituted the control group. Serum vitamin D levels were compared between the groups.<br /> <b>Results:</b> The mean vitamin D level of all patients included in the study, HPV(+) and HPV(-) patients were 17.57±8.73, 17.54±9.20 and 17.63±7.83, respectively. In the study group 10.2% of the patients and in the control group 8.5% had adequate vitamin D levels. No significant differences in vitamin D levels and in terms of distribution according to categorical vitamin D level have been observed between the groups (p=0.774, p=0.989).<br /> <b>Conclusion: </b>Vitamin D levels were comparable between HPV positive and HPV negative groups, but study and controls both had very low sufficient vitamin D levels. In Turkey and especially in our region (Zonguldak), vitamin D deficiency is almost endemic, and this might be the main reason that both of the groups have very similar vitamin D measurements.