Fast dissolving strips: A novel approach for the delivery of verapamil

Objective: Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablets/capsules etc. Verapamil is a calcium channel blocker used as an antianginal, antiarrhythmic, and antihypertensive agent with extensive first pass metabolism which results in l...

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Main Authors: S Kunte (Author), P Tandale (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2010-01-01T00:00:00Z.
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001 doaj_814f1f76d7a44d438e9a47dc77bbcb05
042 |a dc 
100 1 0 |a S Kunte  |e author 
700 1 0 |a P Tandale  |e author 
245 0 0 |a Fast dissolving strips: A novel approach for the delivery of verapamil 
260 |b Wolters Kluwer Medknow Publications,   |c 2010-01-01T00:00:00Z. 
500 |a 0975-7406 
500 |a 0976-4879 
500 |a 10.4103/0975-7406.72133 
520 |a Objective: Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablets/capsules etc. Verapamil is a calcium channel blocker used as an antianginal, antiarrhythmic, and antihypertensive agent with extensive first pass metabolism which results in less bioavailability. This work investigated the possibility of developing verapamil fast dissolving strips allowing fast, reproducible drug dissolution in the oral cavity; thus bypassing first pass metabolism. Materials and methods: The fast dissolving strips were prepared by solvent casting technique with the help of HPMC E6 and maltodextrin. The strips were evaluated for drug content uniformity, film thickness, folding endurance, in vitro disintegration time, in vitro dissolution studies, surface pH study, and palatability study. Results: Official criteria for evaluation parameters were fulfilled by all formulations. Disintegration time showed by formulations was found to be in range of 20.4-28.6 sec. Based on the evaluation parameters, the formulation containing 2% HPMC E6 and 3.5% maltodextrin showed optimum performance against other formulations. Conclusion: It was concluded that the fast dissolving strips of verapamil can be made by solvent casting technique with enhanced dissolution rate, taste masking, and hence better patient compliance and effective therapy 
546 |a EN 
690 |a Fast dissolving strips 
690 |a HPMC E6 
690 |a maltodextrin 
690 |a verapamil 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
690 |a Analytical chemistry 
690 |a QD71-142 
655 7 |a article  |2 local 
786 0 |n Journal of Pharmacy and Bioallied Sciences, Vol 2, Iss 4, Pp 325-328 (2010) 
787 0 |n http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2010;volume=2;issue=4;spage=325;epage=328;aulast=Kunte 
787 0 |n https://doaj.org/toc/0975-7406 
787 0 |n https://doaj.org/toc/0976-4879 
856 4 1 |u https://doaj.org/article/814f1f76d7a44d438e9a47dc77bbcb05  |z Connect to this object online.