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Large variability in plasma efavirenz concentration in Papua New Guinea HIV/AIDS patients associated with high frequency of CYP2B6 516T allele

Abstract Papua New Guinea (PNG) has a high HIV/AIDS prevalence and very high frequency of the CYP2B6 c.516G>T (rs3745274) variant. We have conducted the first investigation of the impact of c.516G>T and patient demographics on plasma efavirenz (EFV) and 8‐hydroxyefavirenz (8OH‐EFV) concentrati...

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Main Authors:	Natália Bordin Andriguetti (Author), Helena Katherina Van Schalkwyk (Author), Daniel Thomas Barratt (Author), Joseph Tucci (Author), Paul Pumuye (Author), Andrew Alexander Somogyi (Author)
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出版:	Wiley, 2021-11-01T00:00:00Z.
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