Nuclear Factor Erythroid 2 Related Factor 2 Activator JC-5411 Inhibits Atherosclerosis Through Suppression of Inflammation and Regulation of Lipid Metabolism

• Main Authors: Xinhai Jiang (Author), Yining Li (Author), Weizhi Wang (Author), Xiaowan Han (Author), Jiangxue Han (Author), Mingzhu Chen (Author), Jing Zhang (Author), Chenyin Wang (Author), Shunwang Li (Author), Jinque Luo (Author), Xiao Wang (Author), Yang Xu (Author), Yanni Xu (Author), Jingcai Cheng (Author), Shuyi Si (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phenethyl isothiocyanate is widely present in cruciferous vegetables with multiple biological effects. Here we reported the antiatherogenic effects and the underlying mechanisms of JC-5411 (Phenethyl isothiocyanate formulation) in vitro and in vivo. Luciferase reporter assay showed that JC-5411 incr...