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Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

Objective: Glucagon-like peptide-1 and glucagon receptor (GLP-1R/GCGR) co-agonism can maximise weight loss and improve glycaemic control in type 2 diabetes and obesity. In this study, we investigated the cellular and metabolic effects of modulating the balance between G protein and β-arrestin-2 recr...

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Main Authors:	Phil Pickford (Author), Maria Lucey (Author), Roxana-Maria Rujan (Author), Emma Rose McGlone (Author), Stavroula Bitsi (Author), Fiona B. Ashford (Author), Ivan R. Corrêa (Author), David J. Hodson (Author), Alejandra Tomas (Author), Giuseppe Deganutti (Author), Christopher A. Reynolds (Author), Bryn M. Owen (Author), Tricia M. Tan (Author), James Minnion (Author), Ben Jones (Author), Stephen R. Bloom (Author)
Format:	Book
Published:	Elsevier, 2021-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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