Myocarditis in dapsone-induced drug reaction with eosinophilia and systemic symptoms-a case report and review of the literature

Dapsone (4,4'-diaminodiphenylsulfone) has been used for a variety of dermatological conditions. Dapsone-induced drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe drug reaction characterized by fever, cutaneous eruption, and systemic involvement. We present a cas...

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Main Authors: Wei-Hsuan Li (Author), Han-Nan Liu (Author), Ding-Dar Lee (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2011-06-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Wei-Hsuan Li  |e author 
700 1 0 |a Han-Nan Liu  |e author 
700 1 0 |a Ding-Dar Lee  |e author 
245 0 0 |a Myocarditis in dapsone-induced drug reaction with eosinophilia and systemic symptoms-a case report and review of the literature 
260 |b Wolters Kluwer Medknow Publications,   |c 2011-06-01T00:00:00Z. 
500 |a 1027-8117 
500 |a 10.1016/j.dsi.2011.05.005 
520 |a Dapsone (4,4'-diaminodiphenylsulfone) has been used for a variety of dermatological conditions. Dapsone-induced drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe drug reaction characterized by fever, cutaneous eruption, and systemic involvement. We present a case of dapsone-induced DRESS, which resulted in fever, maculopapular eruptions progressing to exfoliative dermatitis, cervical lymphadenopathy, transaminitis, and hypersensitivity myocarditis resulting in congestive heart failure. This patient was withdrawn from dapsone and treated with systemic corticosteroids, but he finally passed away despite aggressive intensive care. We report this rare case and review the literature concerning DRESS with cardiac involvement. 
546 |a EN 
690 |a Dapsone 
690 |a Drug hypersensitivity 
690 |a Myocarditis 
690 |a Dermatology 
690 |a RL1-803 
655 7 |a article  |2 local 
786 0 |n Dermatologica Sinica, Vol 29, Iss 2, Pp 63-66 (2011) 
787 0 |n http://www.sciencedirect.com/science/article/pii/S1027811711000358 
787 0 |n https://doaj.org/toc/1027-8117 
856 4 1 |u https://doaj.org/article/820d2eae90a746f09c0590ef78fd8111  |z Connect to this object online.