Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery

Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues associated with their oral delivery. SNEDDSs...

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Main Authors: Aristote B. Buya (Author), Ana Beloqui (Author), Patrick B. Memvanga (Author), Véronique Préat (Author)
Format: Book
Published: MDPI AG, 2020-12-01T00:00:00Z.
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042 |a dc 
100 1 0 |a Aristote B. Buya  |e author 
700 1 0 |a Ana Beloqui  |e author 
700 1 0 |a Patrick B. Memvanga  |e author 
700 1 0 |a Véronique Préat  |e author 
245 0 0 |a Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery 
260 |b MDPI AG,   |c 2020-12-01T00:00:00Z. 
500 |a 10.3390/pharmaceutics12121194 
500 |a 1999-4923 
520 |a Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues associated with their oral delivery. SNEDDSs are composed of an oil phase, surfactant, and cosurfactant or cosolvent. SNEDDSs characteristics, their ability to dissolve a drug, and in vivo considerations are determinant factors in the choice of SNEDDSs excipients. A SNEDDS formulation can be optimized through phase diagram approach or statistical design of experiments. The characterization of SNEDDSs includes multiple orthogonal methods required to fully control SNEDDS manufacture, stability, and biological fate. Encapsulating a drug in SNEDDSs can lead to increased solubilization, stability in the gastro-intestinal tract, and absorption, resulting in enhanced bio-availability. The transformation of liquid SNEDDSs into solid dosage forms has been shown to increase the stability and patient compliance. Supersaturated, mucus-permeating, and targeted SNEDDSs can be developed to increase efficacy and patient compliance. Self-emulsification approach has been successful in oral drug delivery. The present review gives an insight of SNEDDSs for the oral administration of both lipophilic and hydrophilic compounds from the experimental bench to marketed products. 
546 |a EN 
690 |a oral bio-availability 
690 |a self-nano-emulsifying drug-delivery systems (SNEDDSs) 
690 |a oral delivery 
690 |a solubilization 
690 |a food effect 
690 |a Pharmacy and materia medica 
690 |a RS1-441 
655 7 |a article  |2 local 
786 0 |n Pharmaceutics, Vol 12, Iss 12, p 1194 (2020) 
787 0 |n https://www.mdpi.com/1999-4923/12/12/1194 
787 0 |n https://doaj.org/toc/1999-4923 
856 4 1 |u https://doaj.org/article/82272e4bca5b4c73873e7ac6eb8fdc92  |z Connect to this object online.