IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice.

• Main Authors: Thomas R Shelite (Author), Yuejin Liang (Author), Hui Wang (Author), Nicole L Mendell (Author), Brandon J Trent (Author), Jiaren Sun (Author), Bin Gong (Author), Guang Xu (Author), Haitao Hu (Author), Donald H Bouyer (Author), Lynn Soong (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endothelial cells (EC) are the main target for Orientia tsutsugamushi infection and EC dysfunction is a hallmark of severe scrub typhus in patients. However, the molecular basis of EC dysfunction and its impact on infection outcome are poorly understood. We found that C57BL/6 mice that received a le...