Clemastine Fumarate Attenuates Myocardial Ischemia Reperfusion Injury Through Inhibition of Mast Cell Degranulation

• Main Authors: Shuqi Meng (Author), Xiaotong Sun (Author), Zhaodong Juan (Author), Mingling Wang (Author), Ruoguo Wang (Author), Lina Sun (Author), Yaozu Li (Author), Anran Xin (Author), Shuping Li (Author), Yao Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mast cell (MC) activation is associated with myocardial ischemia reperfusion injury (MIRI). Suppression of MC degranulation might be a target of anti-MIRI. This study aimed to determine whether clemastine fumarate (CLE) could attenuate MIRI by inhibiting MC degranulation. A rat ischemia and reperfus...