Phenytoin- and amlodipine-induced gingival overgrowth
Drug-induced gingival overgrowth is an adverse event associated with three types of drugs, i.e., anticonvulsants, immunosuppressants, and calcium-channel blockers. It was shown that the combined use of an immunosuppressant (cyclosporine) and a calcium-channel blocker increases the prevalence and sev...
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Elsevier,
2012-03-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_82fc32a11f9945c4a15fb8577b60b81d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Ching-Wen Chang |e author |
| 700 | 1 | 0 | |a Chih-Jen Yang |e author |
| 700 | 1 | 0 | |a Yu-Lin Lai |e author |
| 245 | 0 | 0 | |a Phenytoin- and amlodipine-induced gingival overgrowth |
| 260 | |b Elsevier, |c 2012-03-01T00:00:00Z. | ||
| 500 | |a 1991-7902 | ||
| 500 | |a 10.1016/j.jds.2012.01.013 | ||
| 520 | |a Drug-induced gingival overgrowth is an adverse event associated with three types of drugs, i.e., anticonvulsants, immunosuppressants, and calcium-channel blockers. It was shown that the combined use of an immunosuppressant (cyclosporine) and a calcium-channel blocker increases the prevalence and severity of gingival overgrowth. However, few reports discussed the effects of the combination of an anticonvulsant (phenytoin) and a calcium-channel blocker (amlodipine). In this case report, we present an epilepsy patient who was using both phenytoin and amlodipine, which caused extensive gingival overgrowth. After periodontal treatment and a gingivectomy, the gingival overgrowth was significantly reduced. A postoperative drug-substitution regimen and intensive professional care ensured a stable result 1 year after surgery. | ||
| 546 | |a EN | ||
| 690 | |a amlodipine | ||
| 690 | |a drug-induced gingival overgrowth | ||
| 690 | |a gingivectomy | ||
| 690 | |a phenytoin | ||
| 690 | |a Dentistry | ||
| 690 | |a RK1-715 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Dental Sciences, Vol 7, Iss 1, Pp 85-88 (2012) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1991790212000141 | |
| 787 | 0 | |n https://doaj.org/toc/1991-7902 | |
| 856 | 4 | 1 | |u https://doaj.org/article/82fc32a11f9945c4a15fb8577b60b81d |z Connect to this object online. |