Discovery of novel IDH1-R132C inhibitors through structure-based virtual screening

• Main Authors: Chujiao Hu (Author), Zhirui Zeng (Author), Dan Ma (Author), Zhixin Yin (Author), Shanshan Zhao (Author), Tengxiang Chen (Author), Lei Tang (Author), Shi Zuo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isocitrate dehydrogenase (IDH) belongs to a family of enzymes involved in glycometabolism. It is found in many living organisms and is one of the most mutated metabolic enzymes. In the current study, we identified novel IDH1-R132C inhibitors using docking-based virtual screening and cellular inhibit...