Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements

• Main Authors: Yoshinori Aoki (Author), Daisuke Nishizawa (Author), Junko Hasegawa (Author), Shinya Kasai (Author), Kaori Yoshida (Author), Yoshihiko Koukita (Author), Tatsuya Ichinohe (Author), Makoto Nagashima (Author), Ryoji Katoh (Author), Yasuo Satoh (Author), Megumi Tagami (Author), Masakazu Hayashida (Author), Ken-ichi Fukuda (Author), Kazutaka Ikeda (Author)
• Format: Book
• Published: Elsevier, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene was suggested by our previous genome-wide association study. To verify this association, we analyzed the association between the rs1465040 SNP and analgesic requirements, including opioid requirements, after open abdominal surgery. The association between the rs1465040 SNP and postoperative analgesic requirements was confirmed in the open abdominal surgery group (P = 0.036), suggesting that the TRPC3 SNP may contribute to predicting postoperative analgesic requirements.

Item Description

1347-8613
10.1016/j.jphs.2015.02.005