Yeast as a tool to decipher the molecular mechanisms underlying the functions of Bcl-2 family
The budding yeast Saccharomyces cerevisiae, a favorite model in biology, does not contain any protein of the Bcl-2 family. From initial experiments with two-hybrid systems to the heterologous expression of human Bcl-2 family members, and the characterization of several forms of yeast programmed cell...
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| Format: | Book |
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Open Exploration Publishing Inc.,
2022-04-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | The budding yeast Saccharomyces cerevisiae, a favorite model in biology, does not contain any protein of the Bcl-2 family. From initial experiments with two-hybrid systems to the heterologous expression of human Bcl-2 family members, and the characterization of several forms of yeast programmed cell death, it has however always been a powerful tool to gain information on the mechanisms of apoptosis in general and on Bcl-2 family in particular. This is a short survey of 25 years of experiments that have provided, and at times initiated, insights into the molecular mechanisms underlying the function of Bcl-2 family members. |
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| Item Description: | 10.37349/etat.2022.00076 2692-3114 |