Potential Antimetastatic Effect of Timosaponin AIII against Human Osteosarcoma Cells through Regulating the Integrin/FAK/Cofilin Axis

• Main Authors: Yi-Hsien Hsieh (Author), Wen-Hung Hsu (Author), Shun-Fa Yang (Author), Chung-Jung Liu (Author), Ko-Hsiu Lu (Author), Pei-Han Wang (Author), Renn-Chia Lin (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Timosaponin AIII (TSAIII) is a steroidal saponin which demonstrates anti-tumour activities. However, the effect of TSAIII on human osteosarcoma cells remains largely unknown. In this study, we demonstrated that TSAIII exerted a significant inhibitory effect on the distribution of cytoskeletal F-acti...