Efficacy of Short Novel Antimicrobial Peptides in a Mouse Model of <i>Staphylococcus pseudintermedius</i> Skin Infection
As the clinical application of antibiotics for bacterial skin infections in companion animals becomes increasingly prevalent, the issue of bacterial resistance has become more pronounced. Antimicrobial peptides, as a novel alternative to traditional antibiotics, have garnered widespread attention. I...
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| Format: | Book |
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MDPI AG,
2024-05-01T00:00:00Z.
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| Summary: | As the clinical application of antibiotics for bacterial skin infections in companion animals becomes increasingly prevalent, the issue of bacterial resistance has become more pronounced. Antimicrobial peptides, as a novel alternative to traditional antibiotics, have garnered widespread attention. In our study, synthetic peptides ADD-A and CBD3-ABU were tested against <i>Staphylococcus pseudintermedius</i> skin infections in KM mice. ADD-A was applied topically and through intraperitoneal injection, compared with control groups and treatments including CBD3-ABU, ampicillin sodium, and saline. Wound contraction, bacterial counts and histology were assessed on days 3 and 11 post-infection. ADD-A and ampicillin treatments significantly outperformed saline in wound healing (<i>p</i> < 0.0001 and <i>p</i> < 0.001, respectively). ADD-A also showed a markedly lower bacterial count than ampicillin (<i>p</i> < 0.0001). Histologically, ADD-A-applied wounds had better epidermal continuity and a thicker epidermis than normal, with restored follicles and sebaceous glands. ADD-A's effectiveness suggests it as a potential alternative to antibiotics for treating skin infections in animals. |
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| Item Description: | 10.3390/antibiotics13060508 2079-6382 |