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Cryptogenic hepatitis patients have a higher Bartonella sp.-DNA detection in blood and skin samples than patients with non-viral hepatitis of known cause

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<h4>Background</h4> This study aimed to assess the prevalence of Bartonella sp.-DNA detection in blood and skin samples from patients with non-viral end-stage liver disease awaiting liver transplantation. <h4>Methodology/Principal findings</h4> Blood samples and healthy skin...

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Main Authors: Marina Rovani Drummond (Author), Luciene Silva dos Santos (Author), Renata Soalheiro Fávaro (Author), Raquel Silveira Bello Stucchi (Author), Ilka de Fátima Santana Ferreira Boin (Author), Paulo Eduardo Neves Ferreira Velho (Author)
Format: Book
Published: Public Library of Science (PLoS), 2022-07-01T00:00:00Z.
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Summary:<h4>Background</h4> This study aimed to assess the prevalence of Bartonella sp.-DNA detection in blood and skin samples from patients with non-viral end-stage liver disease awaiting liver transplantation. <h4>Methodology/Principal findings</h4> Blood samples and healthy skin fragments from 50 patients were tested using microbiological and molecular methods. Fifteen patients had cryptogenic hepatitis (CH) and 35 had alcoholic, drug-induced or autoimmune liver disease. DNA was extracted from whole blood and liquid culture samples, isolates, and skin fragments. Thirteen of the 50 patients (26%) had Bartonella henselae DNA detection in their blood (9/50) and/or skin (5/50) samples. Colonies were isolated in 3/50 (6%) and infection was detected in 7/50 (14%) of the 50 patients. B. henselae-DNA detection was more prevalent in patients with CH than in other patients (p = 0.040). Of 39 patients followed-up for at least two years, a higher mortality rate was observed among patients with CH infected with B. henselae (p = 0.039). <h4>Conclusions/Significance</h4> Further studies assessing the role of B. henselae infection in the pathogenesis of hepatitis patients must be urgently conducted. Author summary One in four patients with end-stage liver disease awaiting liver transplantation for hepatitis of non-viral origin had documented B. henselae-DNA detection and cryptogenic hepatitis patients have a higher bacterium molecular detection than patients with non-viral hepatitis of known cause.
Item Description:1935-2727
1935-2735

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