Multistage delivery of CDs-DOX/ICG-loaded liposome for highly penetration and effective chemo-photothermal combination therapy
Nanoparticles (NPs) have proven to be effective drug carriers in diagnosis and therapy of cancer. But, they faced a contradictory issue that NPs with large size appear weak tumor penetration, meanwhile small size resulted in poor tumor retention. Herein, we fabricated doxorubicin conjugated carbon d...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Book |
| Published: |
Taylor & Francis Group,
2018-01-01T00:00:00Z.
|
| Subjects: | |
| Online Access: | Connect to this object online. |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_83cbbace86a5499f9a1be5f0591a1fb7 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Xiao Xue |e author |
| 700 | 1 | 0 | |a Ting Fang |e author |
| 700 | 1 | 0 | |a Luyao Yin |e author |
| 700 | 1 | 0 | |a Jianqi Jiang |e author |
| 700 | 1 | 0 | |a Yunpeng He |e author |
| 700 | 1 | 0 | |a Yinghui Dai |e author |
| 700 | 1 | 0 | |a Dongkai Wang |e author |
| 245 | 0 | 0 | |a Multistage delivery of CDs-DOX/ICG-loaded liposome for highly penetration and effective chemo-photothermal combination therapy |
| 260 | |b Taylor & Francis Group, |c 2018-01-01T00:00:00Z. | ||
| 500 | |a 1071-7544 | ||
| 500 | |a 1521-0464 | ||
| 500 | |a 10.1080/10717544.2018.1482975 | ||
| 520 | |a Nanoparticles (NPs) have proven to be effective drug carriers in diagnosis and therapy of cancer. But, they faced a contradictory issue that NPs with large size appear weak tumor penetration, meanwhile small size resulted in poor tumor retention. Herein, we fabricated doxorubicin conjugated carbon dots (CDs-DOX) and indocyanine green (ICG)-loaded liposomes (ICG-LPs) named CDs-ICG-LPs using a modified reverse phase evaporation process, and with high incorporation in the aqueous core. The CDs-ICG-LPs exhibited good monodispersity, excellent fluorescence/size stability, and consistent spectra characteristics compared with free ICG or DOX. Moreover, the CDs-ICG-LPs showed higher temperature response, faster DOX release under laser irradiation. In the meantime, the fluorescence of DOX and ICG in CDs-ICG-LPs was also visualized for the process of subcellular location in vitro. In comparison with chemo or photothermal treatment alone, the combined treatment of CDs-ICG-LPs with laser irradiation synergistically induced the apoptosis and death of DOX-sensitive HepG2 cells. In vivo antitumor activities demonstrated CDs-ICG-LPs could reach higher antitumor activity compared with CDs-DOX and ICG-LPs for H22 tumor cells, and suppressed H22 tumor growth in vivo. Notably, no systemic toxicity occurrence was observed after repeated dose of CDs-ICG-LPs with laser irradiation. Hence, the well-defined CDs-ICG-LPs exhibited great potential in targeting cancer imaging and chemo-photothermal therapy. | ||
| 546 | |a EN | ||
| 690 | |a carbon dots | ||
| 690 | |a doxorubicin | ||
| 690 | |a indocyanine green | ||
| 690 | |a liposome | ||
| 690 | |a highly penetration | ||
| 690 | |a chemo-photothermal | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Drug Delivery, Vol 25, Iss 1, Pp 1826-1839 (2018) | |
| 787 | 0 | |n http://dx.doi.org/10.1080/10717544.2018.1482975 | |
| 787 | 0 | |n https://doaj.org/toc/1071-7544 | |
| 787 | 0 | |n https://doaj.org/toc/1521-0464 | |
| 856 | 4 | 1 | |u https://doaj.org/article/83cbbace86a5499f9a1be5f0591a1fb7 |z Connect to this object online. |