Antimicrobial, Probiotic, and Immunomodulatory Potential of <i>Cannabis sativa</i> Extract and Delivery Systems
The compounds present in hemp show multidirectional biological activity. It is related to the presence of secondary metabolites, mainly cannabinoids, terpenes, and flavonoids, and the synergy of their biological activity. The aim of this study was to assess the activity of the Henola <i>Cannab...
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| Main Authors: | , , , |
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| Format: | Book |
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MDPI AG,
2024-04-01T00:00:00Z.
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| Summary: | The compounds present in hemp show multidirectional biological activity. It is related to the presence of secondary metabolites, mainly cannabinoids, terpenes, and flavonoids, and the synergy of their biological activity. The aim of this study was to assess the activity of the Henola <i>Cannabis sativae</i> extract and its combinations with selected carriers (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, magnesium aluminometasilicate, and hydroxypropyl-β-cyclodextrin) in terms of antimicrobial, probiotic, and immunobiological effects. As a result of the conducted research, the antimicrobial activity of the extract was confirmed in relation to the following microorganisms: <i>Clostridium difficile</i>, <i>Listeria monocytogenes</i>, <i>Enterococcus faecalis</i>, <i>Staphylococcus aureus</i>, <i>Staphylococcus pyrogenes</i>, <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, <i>Salmonella typhimurium</i>, <i>Pseudomonas aereuginosa</i>, and <i>Candida albicans</i> (microorganism count was reduced from ~10<sup>2</sup> CFU mL<sup>−1</sup> to <10 CFU mL<sup>−1</sup> in most cases). Additionally, for the system with hydroxypropyl-β-cyclodextrin, a significant probiotic potential against bacterial strains was established for strains <i>Lactobacillus acidophilus</i>, <i>Lactobacillus casei</i>, <i>Lactobacillus plantarum</i>, <i>Lactobacillus brevis</i>, <i>Lactobacillus rhamnosus</i>, <i>Lactobacillus reuteri</i>, <i>Pediococcus pentosaceus</i>, <i>Lactococcus lactis</i>, <i>Lactobacillus fermentum</i>, and <i>Streptococcus thermophilus</i> (microorganism count was increased from ~10<sup>2</sup> to 10<sup>4</sup>-10<sup>7</sup>). In terms of immunomodulatory properties, it was determined that the tested extract and the systems caused changes in IL-6, IL-8, and TNF-α levels. |
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| Item Description: | 10.3390/antibiotics13040369 2079-6382 |