Theoretical and Practical Issues That Are Relevant When Scaling Up hMSC Microcarrier Production Processes

• Main Authors: Valentin Jossen (Author), Cedric Schirmer (Author), Dolman Mostafa Sindi (Author), Regine Eibl (Author), Matthias Kraume (Author), Ralf Pörtner (Author), Dieter Eibl (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The potential of human mesenchymal stem cells (hMSCs) for allogeneic cell therapies has created a large amount of interest. However, this presupposes the availability of efficient scale-up procedures. Promising results have been reported for stirred bioreactors that operate with microcarriers. Recen...