Repositioning of Tamoxifen in Surface-Modified Nanocapsules as a Promising Oral Treatment for Visceral Leishmaniasis

• Main Authors: Débora Faria Silva (Author), Levi Eduardo Soares Reis (Author), Marina Guimarães Carvalho Machado (Author), Douglas Daniel Dophine (Author), Vinicius Roberto de Andrade (Author), Wanderson Geraldo de Lima (Author), Margareth Spangler Andrade (Author), José Mário Carneiro Vilela (Author), Alexandre Barbosa Reis (Author), Gwenaelle Pound-Lana (Author), Simone Aparecida Rezende (Author), Vanessa Carla Furtado Mosqueira (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Standards of care for human visceral leishmaniasis (VL) are based on drugs used parenterally, and oral treatment options are urgently needed. In the present study, a repurposing strategy was used associating tamoxifen (TMX) with polyethylene glycol-<i>block</i>-polylactide nanocapsules (...