Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria
Abstract Patients with cerebral malaria with polymorphic Cytochrome P450 2C19 (CYP2C19) genotypes who receive concurrent treatment with quinine are at risk of inadequate or toxic therapeutic drug concentrations due to metabolic drug interactions. The study aimed to predict the potential dose regimen...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
Wiley,
2022-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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