β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund's adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway
Rheumatoid arthritis (RA), autoimmune disease that is categorized via chronic inflammation manifestation, obesity, cardiovascular risk and even enhanced the mortality and affect the 0.3 and 1% of population worldwide. The current experimental study was scrutinize the anti-arthritic effect of β-sitos...
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Taylor & Francis Group,
2020-01-01T00:00:00Z.
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LEADER | 00000 am a22000003u 4500 | ||
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001 | doaj_8473750fd53e467ea5e136b0d2c02f16 | ||
042 | |a dc | ||
100 | 1 | 0 | |a Feng Zhang |e author |
700 | 1 | 0 | |a Zhiyu Liu |e author |
700 | 1 | 0 | |a Xijing He |e author |
700 | 1 | 0 | |a Zhanqi Li |e author |
700 | 1 | 0 | |a Bin Shi |e author |
700 | 1 | 0 | |a Fengmei Cai |e author |
245 | 0 | 0 | |a β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund's adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway |
260 | |b Taylor & Francis Group, |c 2020-01-01T00:00:00Z. | ||
500 | |a 1071-7544 | ||
500 | |a 1521-0464 | ||
500 | |a 10.1080/10717544.2020.1818883 | ||
520 | |a Rheumatoid arthritis (RA), autoimmune disease that is categorized via chronic inflammation manifestation, obesity, cardiovascular risk and even enhanced the mortality and affect the 0.3 and 1% of population worldwide. The current experimental study was scrutinize the anti-arthritic effect of β-sitosterol loaded solid lipid nanoparticles (SLN) against complete Fruend adjuvant (CFA)-induced arthritis via dual pathway. Double emulsion solvent displacement method was used for the preparation of β-sitosterol solid lipid nanoparticles (SLN). CFA was used to induce arthritis and rats were divided into different groups for 28 days. Biochemical, anti-inflammatory, pro-inflammatory cytokines and inflammatory mediator were estimated, respectively. Receptor activator of nuclear factor kappa-B ligand (RANKL), signal transducer and activator of transcription-3 (STAT3) nuclear factor erythroid 2-related factor 2 (Nrf2), Heme Oxygenase-1(HO-1) and Nuclear factor-κB (NF-κB) expression were estimated. β-sitosterol-SLN significantly (p < .001) reduced the paw edema, arthritic index and increased the body weight. β-sitosterol-SLN increased the redox status of synovium {reduce the malonaldehyde (MDA) and increase superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT)} level and reduced the cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-2, interleukin-6, interleukin-16, interleukin-17 and increased level of interleukin-10, Transforming growth factor beta (TGF-β). β-sitosterol-SLN significantly (p < .001) reduced the level of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), vascular Endothelial Growth Factor (VEGF) and NF-κB. β-sitosterol-SLN significantly increased the expression of HO-1,Nrf2 and decreased the expression of NF-κB, RANKL, STAT3. In conclusion, β-sitosterol SLN showed the antiarthritic effect via suppression of NF-kB and activation of HO-1/Nrf-2 pathway. | ||
546 | |a EN | ||
690 | |a β-sitosterol | ||
690 | |a nanoparticles | ||
690 | |a arthritis | ||
690 | |a inflammation | ||
690 | |a ho-1/nrf2 pathway | ||
690 | |a Therapeutics. Pharmacology | ||
690 | |a RM1-950 | ||
655 | 7 | |a article |2 local | |
786 | 0 | |n Drug Delivery, Vol 27, Iss 1, Pp 1329-1341 (2020) | |
787 | 0 | |n http://dx.doi.org/10.1080/10717544.2020.1818883 | |
787 | 0 | |n https://doaj.org/toc/1071-7544 | |
787 | 0 | |n https://doaj.org/toc/1521-0464 | |
856 | 4 | 1 | |u https://doaj.org/article/8473750fd53e467ea5e136b0d2c02f16 |z Connect to this object online. |